April 19, 2022

Calico’s Cynthia Kenyon on The Science of Aging

For millennia, humans have believed that aging is inevitable. Yet thirty years ago, the work of Professor Cynthia Kenyon and her colleagues showed that a single gene mutation in a worm doubled its lifespan and postponed the diseases of aging. …

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April 12, 2022

Geoffrey Hinton on the Exploration of Thought

What is a thought? Some may think that question is quite abstract, but it has huge implications for science and computer design.

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April 5, 2022

The Future of Psychiatry with Professor Karl Deisseroth

Psychiatry is changing and will be unrecognizable in the next 10-20 years, given our new understanding about the role of brain circuits in the generation of emotions and behavior. This week we talk to Professor Karl Deisseroth, D.H. Chen Professor …

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March 29, 2022

An Exploration of Protein Folding with Professor David Baker

This week we speak with Professor David Baker about the enormous scope for making new proteins and how that translates into practical uses to tackle diseases, such as Covid-19.

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March 22, 2022

The Future of Cancer Medicine with Dr. Jay Bradner, President of Nova…

In the last 20 years or so, many new cancer treatments have emerged that provide greater precision and targeting of cancer cells. Today, we have a better understanding of the genetic components of cancer. Through novel technology and cutting-edge science, …

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March 15, 2022

Breaking Barriers in Gene Editing with Harvard Professor David Liu

Genome editing holds the potential to be a transformative new therapy, and the pace of progress is truly breathtaking.

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March 8, 2022

The "Dark Genome" with Dr. Rosana Kapeller-Lieberman

In this episode we explore the vastness of the dark genome and why "junk DNA" has been overlooked for so many decades.

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June 10, 2021

Bonus: The Patient's Perspective with Julia Vitarello

Julia Vitarello is the mother of Mila Makovec, and the Founder and CEO of Mila’s Miracle Foundation.

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June 3, 2021

Genentech’s Aviv Regev on the Promise of Single Cell Genomics

Aviv Regev is a computational biologist and Executive Vice President of Genentech Research and Early Development. She was professor at the Broad Institute of MIT and Harvard and at the Department of Biology of the Massachusetts Institute of Technology, as …

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May 27, 2021

Dr. Amy Abernethy on Closing the Gap Between Clinical Practice and Cl…

Dr. Amy Abernethy is an oncologist, specialist in palliative care medicine, researcher, previous Professor of Medicine at Duke University School of Medicine, previous Scientific and Medical Chief Officer of Flatiron Health, and previous Principal Deputy Commissioner of the FDA.

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May 20, 2021

Dr. David Altshuler on Translating the Human Genome Project Into Bene…

David Altshuler is Executive Vice President, Global Research and Chief Scientific Officer at Vertex Pharmaceuticals.

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May 13, 2021

Dr. Tim Yu on Running the First “N of 1” Drug Trial

Dr. Timothy Yu walks us through his experience running the first "N of 1" drug trial for a young patient with a devastating genetic mutation.

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May 6, 2021

Dr. Krishna Yeshwant on Exploring the Intersection of Technology and …

Dr. Krishna Yeshwant is Managing Partner at GV, and a practicing physician at Brigham and Women’s Hospital in Boston.

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April 29, 2021

Dr. Caroline Uhler on Harnessing the Power of Machine Learning to Dri…

Theory and Practice speaks with Dr. Caroline Uhler, currently the Henry L. and Grace Doherty associate professor in EECS (Electrical Engineering & Computer Science) and IDSS (Institute for Data, Systems and Society) at MIT, and associate member of the Broad …

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April 22, 2021

Dr. Jennifer Listgarten on Solving Biological Questions with Creative…

Theory and Practice speaks with Professor Jennifer Listgarten, Professor in UC Berkeley's Electrical Engineering and Computer Sciences Department (EECS department) and the Center for Computational Biology, and Chan Zuckerberg investigator.

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April 15, 2021

Sir Rory Collins on the Power of Math and Biomedical Data to Solve To…

Theory and Practice speaks with Professor Sir Rory Collins, Head of Nuffield Department of Population Health at Oxford University and BHF (British Heart Foundation) Professor of Medicine and Epidemiology. Professor Collins is also Principal Investigator and Chief Executive of the …

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April 8, 2021

A Conversation with the Broad Institute's Anne Carpenter

Dr. Anne Carpenter is the inventor of CellProfiler and designed a method for coloring and analyzing cells. She works at the Broad Institute as the Senior Director of the Imaging Platform and is an Institute Scientist.

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April 2, 2021

Season Two Coming Soon

One week until Theory and Practice returns! Join Anthony and Alex as they discuss cutting-edge health developments with leaders in biology and computer science.

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March 4, 2020

Alexis Borisy, Finale Doshi-Velez, Pardis Sabeti

The hosts interview a panel of distinguished guests, including life sciences entrepreneur and investor Alexis Borisy, Finale Doshi-Velez of Harvard University's John A. Paulson School of Engineering and Applied Sciences, and Pardis Sabeti of the Broad Institute of MIT and …

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Feb. 19, 2020

Zach Weinberg, Flatiron Health

Zach Weinberg is the co-founder, president, and COO of Flatiron Health. He discusses his entrepreneurial journey and Flatiron Health's approach to accelerating cancer care and improving patient outcomes.

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Feb. 5, 2020

Cori Bargmann, Chan Zuckerberg Initiative

Cori Bargmann is the head of science at the Chan Zuckerberg Initiative. She is also the head of the Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior and the Torsten N. Wiesel Professor at The Rockefeller University in …

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Jan. 22, 2020

Daphne Koller, insitro

Professor Daphne Koller is the CEO and founder of insitro. She joins the podcast to discuss how machine learning and biology can advance drug discovery and patient care.

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Jan. 8, 2020

David Sontag, MIT

David Sontag, Associate Professor of Electrical Engineering and Computer Science at MIT, explores how artificial intelligence can transform medicine, and discusses the importance of fairness in machine learning.

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Dec. 11, 2019

Eric Lander, Broad Institute

Eric Lander, president and founding director of the Broad Institute of MIT and Harvard, joins the show to discuss human genetics and computational biology.

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